abstract：:Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have b...

journal_title：Current pharmaceutical biotechnology

authors： Tejada S,Manayi A,Daglia M,Nabavi SF,Sureda A,Hajheydari Z,Gortzi O,Pazoki-Toroudi H,Nabavi SM

更新日期：2016-07-21 00:00:00

abstract：:Lipid nanocapsules (LNCs) were designed more than 15 years ago to deliver lipophilic drugs to cells with non toxic excipients by mimicking lipoproteins. During the last 5 years these promising nanocarriers were re-designed to deliver nucleic acids to cancer cells. This short review sums up the features of LNCs and des...

journal_title：Current pharmaceutical biotechnology

authors： Lagarce F,Passirani C

更新日期：2016-01-01 00:00:00

abstract：:The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes ...

journal_title：Current pharmaceutical biotechnology

authors： Busardò FP,Vergallo GM,Turillazzi E,Bolino G,Vullo A,Frati P

更新日期：2016-01-01 00:00:00

abstract：:Cancer, as the most serious threat to human health, poses millions of deaths in the world each year. In vitro cancer cell and biomarker detection is of great importance for early cancer diagnosis and therapy, which needs highly sensitive, selective and quantitative diagnosis platforms. Threedimensional paper-based ele...

journal_title：Current pharmaceutical biotechnology

authors： Li Z,Hu J,Xu F,Li F

更新日期：2016-01-01 00:00:00

abstract：:Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

journal_title：Current pharmaceutical biotechnology

authors： Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

更新日期：2016-01-01 00:00:00

abstract：:Cross-border reproductive care (CBRC) is a multifaceted phenomenon. It may involve both the movement of patients to undertake assisted reproductive treatment through technologies otherwise denied and the movement of assisted reproduction professionals, egg and sperm donors and surrogates, as well as the importing and ...

journal_title：Current pharmaceutical biotechnology

authors： Neri M,Turillazzi E,Pascale N,Riezzo I,Pomara C

更新日期：2016-01-01 00:00:00

abstract：:The design and development of novel biological drugs are among the most exciting new areas of biotechnology which are gaining the attention of scientists. In the last few decades several fabrication processes have been proposed and developed for the production of recombinant growth factors. However, traditional produc...

journal_title：Current pharmaceutical biotechnology

authors： Laura W,Pablo L,Arantxa A,Isabel B,Alberto R,Silvia J,Noelia C,de Francisco Ana,Raquel C,Gorka O

更新日期：2016-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is characterized as a heterogeneous disease where the patients are sub grouped according to several classification systems and mutational analyses. Diagnosis of AML is based on identification of the specific myeloid cell initiating the disease, quantification of immature blasts in bone mar...

journal_title：Current pharmaceutical biotechnology

authors： Forthun RB,Hinrichs C,Dowling TH,Bruserud Ø,Selheim F

更新日期：2016-01-01 00:00:00

abstract：:Intra-uterine growth retardation (IUGR) represents one of the major problems in perinatal medicine. IUGR is one of main causes of perinatal mortality and morbidity. A huge number and variety of established and possible causes of IUGR have been described. There are currently no data about effective treatment of this fe...

journal_title：Current pharmaceutical biotechnology

authors： Mierzynski R,Dluski D,Darmochwal-Kolarz D,Poniedziałek-Czajkowska E,Leszczynska-Gorzelak B,Kimber-Trojnar Z,Agnieszka-Wankowicz,Oleszczuk J

更新日期：2016-01-01 00:00:00

abstract：:In recent years, many systems biology approaches have been used with various cancers. The materials described here can be used to build bases to discover novel cancer therapy targets in connection with computer-aided drug design (CADD). A deeper understanding of the mechanisms of cancer will provide more choices and c...

journal_title：Current pharmaceutical biotechnology

authors： Wong YH,Chiu CC,Lin CL,Chen TS,Jheng BR,Lee YC,Chen J,Chen BS

更新日期：2016-01-01 00:00:00

abstract：:Even though malnutrition is associated with an adverse prognosis after allogeneic stem cell transplantation, few studies have addressed the question what is the optimal nutritional support for these patients. There is a general agreement that the body weight, body mass index and nutritional intake can be used to guide...

journal_title：Current pharmaceutical biotechnology

authors： Tvedt TH,Reikvam H,Bruserud Ø

更新日期：2016-01-01 00:00:00

abstract：:We aim to determine the regulation of apoptosis by paclitaxel-induced and understand cancer dynamics to treatment targets for HeLa cells by identifying decrease/increase genes expression on HeLa cells. In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the c...

journal_title：Current pharmaceutical biotechnology

authors： Serbes U,Ozsoylemez OD,Ozcan G

更新日期：2016-01-01 00:00:00

abstract：:Objective: CME-1 is a polysaccharide purified from the mycelia of medicinal mushroom Cordyceps sinensis, its molecular weight was determined to be 27.6 kDa by using nuclear magnetic resonance and gas chromatography-mass spectrometry. The initiation of arterial thromboses is relevant to various cardiovascular diseases ...

journal_title：Current pharmaceutical biotechnology

authors： Chang YI,Hsu WH,Lu WJ,Jayakumar T,Liao JC,Lin MJ,Wang SH,Geraldine P,Lin KH,Sheu JR

更新日期：2015-03-03 00:00:00

abstract：:Plants are rich in a wide variety of secondary metabolites with antimicrobial properties. Phytochemistry studies on the plants extracts in general, and on essential oils (EOs) in particular are focused on the isolation and identification of the components of complex mixtures, in order to determine structure - activity...

journal_title：Current pharmaceutical biotechnology

authors： Saviuc CM,Drumea V,Olariu L,Chifiriuc MC,Bezirtzoglou E,Lazăr V

更新日期：2015-01-01 00:00:00

abstract：:Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV r...

journal_title：Current pharmaceutical biotechnology

authors： Farooqi AA,Li RN,Huang HW,Ismail M,Yuan SS,Wang HM,Liu JR,Tang JY,Chang HW

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The aim of the work was to evaluate the effect of moderate physical exercise on the response of circulating phagocytes to the antineoplastic drug NSC 631570. METHODS:Eight healthy adult men aged 23 ± 2 years were recruited to participate in the study; NSC 631570 was administered i.v. in a single therapeutic ...

journal_title：Current pharmaceutical biotechnology

authors： Skivka LM,Fedorchuk OG,Susak YM,Susak MY,Malanchuk OM,Rudyk MP,Nowicky YW

更新日期：2015-01-01 00:00:00

abstract：:Tumor immune surveillance paradigm presumes that most pre-malignant cells or early malignant lesions can be eliminated (or at least controlled) by cells of the immune system. A critical feature that distinguishes advanced tumors from early neoplastic lesions is their capability to evade immune control. As a consequenc...

journal_title：Current pharmaceutical biotechnology

authors： Klener P Jr,Otáhal P,Lateckova L,Klener P

更新日期：2015-01-01 00:00:00

abstract：:Active or passive immunotherapy is expected to slow or stop the pathological process of Alzheimer's disease (AD). Immunotherapy for AD has demonstrated that targeting beta-amyloid (Aβ) or tau protein with vaccines or antibodies can reduce AD pathologies. Active anti-Aβ immunization for AD includes using AN1792 and sec...

journal_title：Current pharmaceutical biotechnology

authors： Yang C,Xiao S

更新日期：2015-01-01 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：:A novel steroidal oxime (SO) was synthesized using an economic method and then characterized by Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR). When dispersed in pure water, SO can self-assemble into a nano-scale circular structure which was verified by dynamic light scattering (DLS) and tra...

journal_title：Current pharmaceutical biotechnology

authors： Chou TH,Chen CW

更新日期：2015-01-01 00:00:00

abstract：:Mammalian cells are involved in a range of biotechnological applications and more recently have been increasingly exploited in regenerative medicine. Critical to successful applications involving mammalian cells are their long-term storage and transport, for which cryopreservation in liquid nitrogen is the most freque...

journal_title：Current pharmaceutical biotechnology

authors： Chau DY,Dennis AR,Lin H,Zeitler JA,Tunnacliffe A

更新日期：2015-01-01 00:00:00

abstract：:Proliposomes are phospholipid based drug delivery systems that are finding important applications in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways has not y...

journal_title：Current pharmaceutical biotechnology

authors： Nekkanti V,Venkatesan N,Betageri GV

更新日期：2015-01-01 00:00:00

abstract：:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered wi...

journal_title：Current pharmaceutical biotechnology

authors： Nasr M,Abdel-Hamid S

更新日期：2015-01-01 00:00:00

abstract：:Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflamma...

journal_title：Current pharmaceutical biotechnology

authors： Severino P,Andreani T,Chaud MV,Benites CI,Pinho SC,Souto EB

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The goals of this study were to observe how luteolin protects endothelial cells (ECs) from injury stimulated by Angiotensin II (Ang II), investigate the role of vascular endothelial dysfunction in vascular smooth muscle cell proliferation and migration in vitro and investigate its primary mechanism of action....

journal_title：Current pharmaceutical biotechnology

authors： Ding H,Li D,Zhang Y,Zhang T,Zhu H,Xu T,Luo Y,Wang C

更新日期：2014-01-01 00:00:00

abstract：:As sessile and filter-feeding metazoans, marine sponges represent an ecologically important and highly diverse component of marine benthic communities throughout the world. It has been suggested that marine sponges are hosts to many microorganisms which can constitute up to 40-60% of its biomass. Recently, sponges hav...

journal_title：Current pharmaceutical biotechnology

authors： Santos-Gandelman JF,Giambiagi-deMarval M,Oelemann WM,Laport MS

更新日期：2014-01-01 00:00:00

abstract：:Under normal conditions, most of the central nervous system (CNS) is protected by the blood brain barrier (BBB) from systemic inflammation progression and from the infiltration of immune cells. As a consequence, the CNS developed an original way to provide surveillance, defense and repair, which relies on the complex ...

journal_title：Current pharmaceutical biotechnology

authors： Renaud J,Martinoli MG

更新日期：2014-01-01 00:00:00

abstract：:A variety of methods including penetrating enhancers, enzyme inhibitors, as well as cargo mediated drug delivery have been explored to improve the intolerance of parenteral administrated insulin, but little success has been achieved so far. Under this background, cell penetrating peptides (CPPs), with their ability to...

journal_title：Current pharmaceutical biotechnology

authors： Liu E,Sheng J,Ye J,Wang Y,Gong J,Yang VC,Wang J,He H

更新日期：2014-01-01 00:00:00

abstract：:Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human h...

journal_title：Current pharmaceutical biotechnology

authors： Coppo E,Marchese A

更新日期：2014-01-01 00:00:00

abstract：:Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

journal_title：Current pharmaceutical biotechnology

authors： Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

更新日期：2014-01-01 00:00:00

abstract：:Interstitial lung disease (ILD) is one of the most common complications of polymyositis (PM) and dermatomyositis (DM). It is always progressive and does not respond to conventional immunosuppressive agent treatment. Biologics are commonly used in treatment of rheumatic diseases. They are also used in polymyositis and ...

journal_title：Current pharmaceutical biotechnology

authors： Sun Y,He Y,Liu Y,Shi G

更新日期：2014-01-01 00:00:00

abstract：:The clinical recognition and adequate treatment of women with hyperglycemia during pregnancy is significant in order to reduce neonatal complications correlated with gestational diabetes mellitus (GDM). The traditional management of pregnant patients with GDM in whom diet restriction is not sufficient enough involves ...

journal_title：Current pharmaceutical biotechnology

authors： Kimber-Trojnar Ż,Marciniak B,Patro-Malysza J,Skorzynska-Dziduszko K,Poniedzialek-Czajkowska E,Mierzynski R,Galczynski K,Trojnar M,Leszczynska-Gorzelak B,Oleszczuk J

更新日期：2014-01-01 00:00:00

abstract：:Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

journal_title：Current pharmaceutical biotechnology

authors： Jalink K,Adjobo-Hermans MJ

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs are small non-coding RNA molecules which do not code for proteins, but control the expression of a significant proportion of the genome. The microRNA expression differences of normal and malignant tissue, as well as the differences in various tumor entities qualify this RNA species as biomarker for cancer pa...

journal_title：Current pharmaceutical biotechnology

authors： Ellinger J,Muller SC

更新日期：2014-01-01 00:00:00

abstract：:Toll-like receptor 9 (TLR9) can sense pathogen DNA and CpG ODN or even self-DNA by trafficking assisted by Unc93B1, an endoplasmic reticulum (ER) transmembrane protein, from ER to endolysosomes or cell surface. In previous study, we found that an oligodeoxynucleotide with CCT repeats (SAT05f) could selectively inhibit...

journal_title：Current pharmaceutical biotechnology

authors： Zhang X,Sun W,Wu X,Wang H,Yan Y,Guo S,Song D,Li H,Gao S,Wang L,Yu Y,Wang L

更新日期：2014-01-01 00:00:00

abstract：:Malignant glioma is a primary tumor of the central nervous system, representing a major cause of mortality in a young, productive subset of population. The management of this neoplasm requires aggressive treatments, including radiotherapy. Accurate imaging plays a central role in treatment planning process with curati...

journal_title：Current pharmaceutical biotechnology

authors： Marvaso G,Barone A,Amodio N,Cascini GL,Scotti V,Bianco C

更新日期：2014-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is widely used to promote tissue repair and accelerate osteogenesis, but there is no agreement about its mechanism of action. We characterized the modulatory effect of PRP on the in vitro osteoblast model SaOS-2, by using cell motility/chemoattraction and osteogenesis/mineralization assays, ...

journal_title：Current pharmaceutical biotechnology

authors： Martinotti S,Mazzucco L,Balbo V,Patrone M,Mozzati M,Ranzato E,Burlando B

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We sought to evaluate the safety of imipenem and meropenem in the treatment of infections in neurosurgical patients. METHODS:An observational retrospective study was conducted of consecutive cases treated with imipenem from Sept. 2007 to Sept. 2009 and meropenem within 1 year from Sept. 2008 in Beijing Tiant...

journal_title：Current pharmaceutical biotechnology

authors： Wu Y,Chen K,Shi Z,Wang Q

更新日期：2014-01-01 00:00:00

abstract：:Beyond their originally sole mechanical function, current drug-eluting stents (DES) implement the concept of local drug delivery for the re-opening of stenotic arterial vessels, and for prevention of in-stent restenosis as one of the major limitations of conventional bare metal stents (BMS). Current DES consist of a p...

journal_title：Current pharmaceutical biotechnology

authors： Sternberg K,Grabow N,Petersen S,Weitschies W,Harder C,Ince H,Kroemer HK,Schmitz KP

更新日期：2013-01-01 00:00:00

abstract：:The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, ...

journal_title：Current pharmaceutical biotechnology

authors： Rodrigues IV,Seibert JB,Carneiro SP,de Souza GH,dos Santos OD,Lopes NP

更新日期：2013-01-01 00:00:00